In vivo measurement of local pulse-wave velocity in the right common carotid artery in mice with PC- Cine-MRI at 17.6 T

نویسندگان

  • V. Herold
  • A. Gotschy
  • C. H. Ziener
  • E. Rommel
  • W. R. Bauer
  • P. M. Jakob
چکیده

Introduction: Mouse models are increasingly used to investigate functional cardiovascular parameters. Pulse-wave velocity (PWV) is an important parameter for the evaluation of the arterial stiffness and cardiovascular risk. Several diseases such as hypertension and arteriosclerosis are associated with vascular remodeling and arterial stiffening. MRI methods have been used to quantify PWV in the murine aorta [1,2]. In this work we demonstrate the ability of high field MRI to quantify PWV in the right common carotid artery.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In vivo measurement of regional and local pulse-wave velocity in mice with MRI at 17.6 T

Mouse models are increasingly used to investigate functional and cardiovascular parameters. Pulse wave velocity (PWV) is an important parameter for the evaluation of the arterial and cardiovascular risk. Several diseases such as hypertension and arteriosclerosis are associated with vascular abnormalities and arterial stiffening. In this work we present two different methods to noninvasively exa...

متن کامل

Measuring the Nitroglycerine-Induced Vasodilation in Carotid Arteries

Introduction: Nitroglycerin is a fast-acting drug that rapidly dilates coronary arteries and thus increases blood flow to these vessels, and increases the blood flow through the lateral vessels to low blood areas. It also reduces both end diastolic pressure and volume of the left ventricular. However, the effect of nitroglycerin on the circulation hemodynamic is not known. Caro...

متن کامل

Fast retrospectively triggered local pulse-wave velocity measurements in mice with CMR-microscopy using a radial trajectory

BACKGROUND The aortic pulse-wave velocity (PWV) is an important indicator of cardiovascular risk. In recent studies MRI methods have been developed to measure this parameter noninvasively in mice. Present techniques require additional hardware for cardiac and respiratory gating. In this work a robust self-gated measurement of the local PWV in mice without the need of triggering probes is propos...

متن کامل

برآورد سرعت موج پالس با استفاده از پارامترهای شریانی استخراج شده از تصاویر فراصوتی کاروتید

  Background & Objective : Several indices have been introduced to estimate arterial stiffness that based on changes in brachial blood pressure. But because of the error resulted by the substitution of brachial blood pressure instead of the other central arteries, such as carotid, it will be very important to present elastic parameter based on the mechanical models without any emphasis on brach...

متن کامل

Assessment of local pulse wave velocity distribution in mice using k-t BLAST PC-CMR with semi-automatic area segmentation

BACKGROUND Local aortic pulse wave velocity (PWV) is a measure for vascular stiffness and has a predictive value for cardiovascular events. Ultra high field CMR scanners allow the quantification of local PWV in mice, however these systems are yet unable to monitor the distribution of local elasticities. METHODS In the present study we provide a new accelerated method to quantify local aortic ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010